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Discovery of cannabinoids (Cannabidiol: CBD) and their pharmacological effects

Success in the extraction of active substances from the cannabis plant began in 1899, but purification was not possible due to the limitations of the available tools. Until the discovery of new analytical methods, High-Performance Liquid Chromatography (HPLC) and the spectrometric method, in 1964, enabled scientists to isolate various pure substances. From the cannabis plant and being able to analyze the molecular structure of each substance. According to the study, cannabis plants contain more than 450 chemicals, more than 60 cannabinoids. (cannabinoids) mainly composed of THC and other substances in the same group such as Cannabinol (CBN), Cannabidiol (CBD), Cannabichromene (CBC), Cannabigerol (CBG), etc. 3,4In addition, several new THC derivatives have been synthesized. Including the discovery of the mechanism of action of substances in this group.

CBD kaufen, on the other hand, has little ability to bind directly to CB1 and CB2 receptors. It is a negative allosteric modulator with the CB1 receptor, which affects the action of other receptors, thereby reducing pain, inflammation, and anxiety. Discovery of the mechanism of action of this group of substances, including the discovery of Endocannabinoids, which are endogenous agonists of cannabinoid receptors such as N-arachidonoyl-ethanolamine (AEA; anandamide) and 2-arachidonoylglycerol (2-AG) 5, has led to a greater understanding of the mechanism of action of these compounds and their side effects. And has been used in research for the benefit of treating symptoms or diseases. As has been compiled as follows:

Research studies on the use of cannabis in the treatment of symptoms and diseases

  1. Reduce nausea Vomiting from chemotherapy (Antiemetic effect) 5: Nabilone and Dronabinol are synthetic THC derivatives, and clinical studies have confirmed that Nabilone effectively reduces nausea. Vomiting was better in patients receiving chemotherapy than the drug. Prochlorperazine, Domperidone, and Alizapride used at the time It has been approved for use in Canada since 1982. Dronabinol has been shown in clinical studies to be effective in reducing nausea. Vomiting is better than medication Chlorpromazine and is as effective as the drug Metoclopramide, and Thiethylperazine is, therefore, both Nabilone (Cesamet™ Valeant Pharmaceuticals North America), and Dronabinol (Marinol®; Solvay Pharmaceuticals, Inc) approved for sale in the United States (1985, 1985) and Canada. (1995, 1995), respectively.
  2. Increase appetite in cancer and AIDS patients (Appetite stimulation) 5: Research shows that THC can help increase appetite in cancer and AIDS patients. When a clinical trial of four to six weeks was established, Dronabinol, a THC derivative, was approved to increase Canada’s appetite (Marinol®; Solvay Pharmaceuticals, Inc).
  3. Reduce pain (Analgesic effect) 5,6: Most cannabinoids, primarily THC, can be used to reduce sudden pain. And chronic (Acute and Chronic pain), mainly used to suppress chronic pain. This is the main reason for using cannabis extract to reduce pain. Clinical trials have shown that THC at doses of 2.5 or 2.7 mg can reduce central neuropathic pain and improve sleep in patients. An aerosol (Oromucosal spray, Nabiximols) using a combination of THC and CBD kaufen has been established, which can help reduce rheumatoid  arthritis. Still, for chronic pain in cancer patients, there is no clear clinical conclusion.
  4. Reduce multiple sclerosis (MS) 5,6: MS is a neurological disorder that often occurs with muscle spasms that cause severe and chronic pain. And found that both patients in the group received only one type of THC, And patients who received a 1-to-0.5 combination of THC and CBD kaufen were able to reduce muscle spasms and relieve such pain and help them sleep. In clinical trials, no severe side effects were found. However, both formulations (The ratio of THC: CBD is 1:0.9) are licensed for prescribing in Canada (Sativex®; GW Pharmaceutical; 2005), England and America.
  5. With the legalization of marijuana in Canada, you can now buy bulk shatter online for a much cheaper price. The cannabis industry is still in its infancy, and it’s inevitable that there will be many changes in the near future. However, it’s important to remember that there are still a lot of opportunities for people to make money right now. If you want to buy shatter in bulk, then Canada is the place to be. You can get bulk shatter from a number of different vendors, and it’s always high quality.

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